A Less Flexible BK Channel Opens More Easily
نویسندگان
چکیده
BK potassium channels regulate spike width and firing rate. A BK point mutation in humans enhances channel activity, leading to epilepsy. In this issue of Neuron, Yang and colleagues use this mutation to demonstrate that channel opening is determined by the flexibility of a region that contains a Ca(2+)-binding site.
منابع مشابه
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ورودعنوان ژورنال:
- Neuron
دوره 66 شماره
صفحات -
تاریخ انتشار 2010